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Comparative Study of Prophylactic and Therapeutic Role of Phenobarbitone in the Hyperbilirubinemia in V.L.B.W Babies with Birth Weight 1000-1499 grams and their Outcome

Management of Neonatal Jaundice in Premature Very Low birth weight babies are difficult as most of such babies are already complicated by serious illnesses like RDS, Apnea of Prematurity, Temperature instability, Sepsis, intraventricular Hemorrhage etc. Prolonged Phototherapy and Exchange transfusions in such babies carries significant risk of Morbidity and mortality. Any Prophylactic drug could help in reducing the severity of jaundice in such babies. We evaluated the prophylactic Role of Phenobarbitone in such babies starting at 6 hours of life and compared with therapeutic doses started after babies developed jaundice from day two onwards with control group who didn’t received any drug and found significant reduced risk of severe jaundice needing prolonged phototherapy in the Prophylactic Group.

Author(s): Hussain Z and Kainth UPS

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