Medical & Clinical Reviews

The Association of Cardiac Morbidities in Type 2 Diabetic Patients; A Meta-Analysis.

Diabetes mellitus especially type 2 is one of the most common chronic diseases prevalent in the whole world. It is a metabolic disorder leading to neuropathy and micro vascular lesion. The later when occurring in coronary vessels is the main contributing factor towards the development of cardiac diseases especially CAD. Our study aims to establish a significant association between the two diseases through the meta-analysis of the related researches done in recent years. Two databases i.e. pub med and google scholar were originally searched to gather all the studies with RCT including the association of diabetes and cardiac disease and were further filtered based on well-defined inclusion and exclusion criteria. The relevant data were extracted from the studies and were analyzed. The final analysis included 6 RCTs and 19,350 patients in total both diabetic (experimental group) and non-diabetic (control), out of which 6,909 suffered from any cardiac morbidity. From these 6,9099 patients, 3,739 patients were diabetic thus indicating a considerable fraction of the diabetic patients suffering from cardiac morbidities. 
Highlights 
The results point towards the conclusion that a significant association exists between type 2 diabetic patients and cardiac morbidities and this association remains unaffected even in the presence of different variables like obesity, blood pressure, etc. Duration of diabetes, baseline maintenance of blood sugar levels by medical treatments also affect the prognosis of diabetes so screening of diabetic patients for cardiac diseases is beneficial.
 

M. Abubakar Shahid Chishti, Zain-ul- Abiddin, Tooba Fida^*