Medical & Clinical Reviews

Xylitol and Fluoride Provide an Alternative Preventive Therapy in Antibiotic Resistance Crisis

An alternative preventive treatment with low calorie five carbon sugar-alcohol (xylitol) in combination with fluoride has been developed. Xylitol phosphate affects the genetic continuity of all diplococcic Gram positive Streptococci are formed. Streptococci oralis (diplococcic) and Streptococci pneumoniae grow similarly in heterogeneity of their growth phases: Pre-competent, competent and post-competent (cluster). If exposed to fluoride, such a cluster breaks apart with an instant increase of titre (there is a high probability to reach ID50 dose). We conclude that fluoride breaks clusters even in stationary phase; but the presence of xylitol phosphate initiates unfolding of bacterial cell walls (peptidoglycan layers) and terminates in their population of spheroplasts, protoplasts and PG fragments. Biological continuity ceases regardless of their antibiotic sensitivity patterns.

Author(s):

Sunil Palchaudhuri, Anubha Palchaudhuri and Shreya Bhattacharyya

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